Mechanisms of protection from humoral rejection by a xenografted liver.

The protection from humoral rejection given by a liver xenograft is species-specific and non-MHC restricted.

Humoral immunity-mediated chronic rejection in liver transplantation is associated with predominant IL-10 expression.

Chronic rejection is a major cause of graft dysfunction and retransplantation after liver allotransplantation. Recent studies have implicated humoral response in this chronic rejection reaction. However, the manner in which humoral response is activated has not been fully investigated. In the present study, we address this question using our previously established chronic allograft liver reject...

The Role of Humoral Alloreactivity in Liver Transplantation: Lessons Learned and New Perspectives

More than ten years after the initial description of the humoral theory of transplantation by Dr. Paul I. Terasaki, the significance of humoral alloimmunity in liver transplantation has yet to be clearly defined. The liver allograft has an inherent tolerogenic capacity which confers its resistance to cell-mediated as well as antibody-mediated rejection. Nevertheless, the protection against allo...

The significance of donor-specific HLA antibodies in rejection and ductopenia development in ABO compatible liver transplantation.

The role of humoral alloreactivity in ABO-compatible liver transplantation remains unclear. To understand the significance of donor-specific HLA alloantibodies (DSA) in liver rejection, we applied the currently used strategy for detection of antibody-mediated rejection of other solid allografts. For this purpose we reviewed the data on 43 recipients of ABO identical/compatible donor livers who ...

Hamster-to-rat liver xenografts protect extrahepatic organs from rejection.

THE liver allograft is relatively resistant to the hyperacute rejection caused by preformed antibodies, I and in some species and strain combinations it is accepted without immunosuppression. 2•3 We have shown a similar resistance of the liver to humoral rejection after hamster to rat xenotransplantation. 4•5 Moreover. it has been shown that the liver allograft can induce tolerance to other org...